1356393-56-0

Basic information

• Product Name: ethyl 2,3,5,6,7,8-hexahydro-1H-pyrrolo[1,2-a]azepine-9-carboxylate
• Synonyms: ethyl 2,3,5,6,7,8-hexahydro-1H-pyrrolo[1,2-a]azepine-9-carboxylate
• CAS NO: 1356393-56-0
• Molecular Weight: 209.288
• Mol File: 1356393-56-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 2,3,5,6,7,8-hexahydro-1H-pyrrolo[1,2-a]azepine-9-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2,3,5,6,7,8-hexahydro-1H-pyrrolo[1,2-a]azepine-9-carboxylate(1356393-56-0)
• EPA Substance Registry System: ethyl 2,3,5,6,7,8-hexahydro-1H-pyrrolo[1,2-a]azepine-9-carboxylate(1356393-56-0)

Safety Data

• Hazardous Substances Data: 1356393-56-0(Hazardous Substances Data)

Upstream product

• 110-52-1 1,4-dibromo-butane 
• 35150-22-2 (Z)-ethyl 2-(pyrrolidin-2-ylidene)acetate 

Relevant articles and documents

Chemoselective intramolecular alkylation of the Blaise reaction intermediates: Tandem one-pot synthesis of exo -cyclic enaminoesters and their applications toward the synthesis of N -heterocyclic compounds

The intramolecular alkylative reactivity and N/C selectivity of the various Blaise reaction intermediates, which are formed from the reaction of the Reformatsky reagents with ω-chloroalkyl nitriles, did not reach the synthetic potential as an entry to exo-cyclic enaminoesters. To circumvent this issue, various additives were investigated, among which the addition of NaHMDS dramatically enhanced the reactivity and N/C selectivity. This modification provided a highly efficient route for the synthesis of various N-fused heterocyclic compounds, as it requires only two steps from nitriles.