135644-36-9

Upstream product

• 41063-30-3 1-(n-propylamino)-2-propanol 
• 107-10-8 propylamine 

Downstream Products

• 804519-27-5 2-amino-4-methyl-1-propyl-1H-pyrrole-3-carbonitrile 

Relevant academic research and scientific papers

Method for preparing 2-amino-4-methyl-1-propyl-1H-pyrrole-3-carbonitrile

The invention discloses a method for preparing 2-amino-4-methyl-1-propyl-1H-pyrrole-3-carbonitrile, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: taking epoxypropane and n-propylamine as raw materials; after hydrogen on a nitrogen atom is protected, oxidizing, removing a protecting group, and cyclizing with malononitrile to obtain the 2-amino-4-methyl-1-propyl-1H-pyrrole-3-carbonitrile. The method has the advantages of high product yield, high purity, accessible raw materials and simple operation, and is beneficial to industrialproduction.

Reactions of a Platinum(III) Dimeric Complex with Alkynes in Water: Novel Approach to α-Aminoketone, α-Iminoketone, and α, β-Diimine via Ketonyl-Pt(III) Dinuclear Complexes

Reaction of the platinum(III) dimeric complex [Pt2(NH 3)4((CH3)3CCONH)2(NO 3)2](NO3)2 (1), prepared in situ by the oxidation of the platinum blue complex [Pt4(NH3) 8((CH3)3CCONH)4](NO 3)5 (2) with Na2S2O8, with terminal alkynes CH≡CR (R = (CH2)nCH 3 (n = 2-5), (CH2)nCH2OH (n = 0-2), CH2OCH3, and Ph), in water gave a series of ketonyl-Pt(III) dinuclear complexes [Pt2(NH3) 4((CH3)3CCONH)2(CH 2COR)](NO3)3 (3, R = (CH2) 2CH3; 4, R = (CH2)3CH3; 5, R = (CH2)4CH3; 6, R = (CH2) 5CH3; 7, R = CH2OH; 8, R = CH 2CH2OH; 9, R = (CH2)2CH 2OH; 10, R = CH2OCH3; 11, R = Ph). Internal alkyne 2-butyne reacted with 1 to form the complex [Pt2(NH 3)4((CH3)3CCONH) 2(CH(CH3)COCH3)](NO3)3 (12). These reactions show that Pt(III) reacts with alkynes to give various ketonyl complexes. Coordination of the triple bond to the Pt(III) atom at the axial position, followed by nucleophilic attack of water and hydrogen shift from the enol to keto form, would be the mechanism. The structures of complexes 3·H2O, 7·0.5C3H4O, 9, 10, and 12 have been confirmed by X-ray diffraction analysis. A competitive reaction between equimolar 1-pentyne and 1-pentene toward 1 produced complex 3 and [Pt2(NH3)4((CH3) 3CCONH)2(CH2CH(OH)CH2CH 2CH3)](NO3)3 (14) at a molar ratio of 9:1, suggesting that alkyne is more reactive than alkene. The ketonyl-Pt(III) dinuclear complexes are susceptible to nucleophiles, such as amines, and the reactions with secondary and tertiary amines give the corresponding α-amino-substituted ketones and the reduced Pt(II) complex quantitatively. In the reactions with primary amines, the once formed α -amino-substituted ketones were further converted to the iminoketones and diimines. The nucleophilic attack at the ketonyl group of the Pt(III) complexes provides a convenient means for the preparation of α-aminoketones, α-iminoketones, and diimines from the corresponding alkynes and amines.

Solubilization-inhibitor and positive resist composition

A positive resist composition comprising an aromatic group-containing alkali-soluble resin and a compound having an ammonium salt as skeleton, as the main components.