135644-97-2Relevant academic research and scientific papers
Aminomethylamide derivatives of (3-oxo-1,2-benzisothiazolin-2-yl)acetic acid and 3-(3-oxo-1,2-benzisothiazolin-2-yl)propionic acid
Slawik, Tomasz
, p. 777 - 780 (2007/10/02)
In the search for pharmacological active new derivatives of 1,2-benzisothiazolin-3-one amides of (3-oxo-1,2-benzisothiazolin-2-yl)acetic acid and 3-(3-oxo-1,2-benzisothiazolin-2-yl)propionic acid were obtained.In reaction of these amides with formaldehyde and various secondary amines the title compounds are formed.Morpholinmethylamide of (3-oxo-1,2-benzisothiazolin-2-yl)acetic acid showed activity against Trichomonas vaginalis.In the reaction of ethyl esters of (3-oxo-1,2-benzisothiazolin-2-yl)acetic- and -propionic acids with hydrazine hydrate products of ring-opening of isothiazole-2,2'-dithio-bis and 2,2'-dithio-bisN-(ethoxycarbonylethyl)benzamide are formed.
