1356475-75-6Relevant academic research and scientific papers
Multicomponent synthesis of new primaquine thiazolidinone derivatives
Neuenfeldt, Patricia D.,Drawanz, Bruna B.,Aguiar, Anna Caroline C.,Figueiredojr. Jr., Flavio,Krettli, Antoniana U.,Cunico, Wilson
, p. 3866 - 3870 (2011)
Primaquine thiazolidinone derivatives, potentially useful as antimalarial agents, were synthesized in good yields by multicomponent reactions of primaquine diphosphate, mercaptoacetic acid, and an optionally substituted benzaldehyde or cyclohexanone for t
Primaquine-thiazolidinones block malaria transmission and development of the liver exoerythrocytic forms
Aguiar, Anna Caroline C.,Figueiredo, Flávio Jr. B.,Neuenfeldt, Patrícia D.,Katsuragawa, Tony H.,Drawanz, Bruna B.,Cunico, Wilson,Sinnis, Photini,Zavala, Fidel,Krettli, Antoniana U.
, (2017/03/20)
Background: Primaquine is an anti-malarial used to prevent Plasmodium vivax relapses and malaria transmission. However, PQ metabolites cause haemolysis in patients deficient in the enzyme glucose-6-phosphate dehydrogenase (G6PD). Fifteen PQ-thiazolidinone
