1356485-81-8

Upstream product

• 108-69-0 3,5-dimethylaminoaniline 
• 2050-45-5 N-acetyl-3,5-dimethylaniline 
• 482639-32-7 2-chloro-5,7-dimethylquinoline-3-carbaldehyde 

Downstream Products

• 604754-35-0 2-((2-aminoethyl)amino)-5,7-dimethylquinoline-3-carbonitrile 
• 1100331-31-4 N-(2-((3-cyano-5,7-dimethylquinolin-2-yl)amino)ethyl)-2-methoxybenzamide 
• 1356485-82-9 N-(2-((3-cyano-5,7-dimethylquinolin-2-yl)amino)ethyl)-4-methoxybenzamide 
• 1100330-67-3 N-(2-((3-cyano-5,7-dimethylquinolin-2-yl)amino)ethyl)benzamide 
• 1356485-86-3 N-(2-((3-cyano-5,7-dimethylquinolin-2-yl)amino)ethyl)-2,4-dimethoxybenzamide 
• 1100331-45-0 N-(2-((3-cyano-5,7-dimethylquinolin-2-yl)amino)ethyl)-3,4-dimethoxybenzamide 
• 1356485-88-5 N-(2-((3-cyano-5,7-dimethylquinolin-2-yl)amino)ethyl)-2,6-dimethoxybenzamide 
• 1356485-89-6 2-(4-(2-methoxybenzoyl)piperazin-1-yl)-5,7-dimethylquinoline-3-carbonitrile 
• 1356485-90-9 2-(4-(3-methoxybenzoyl)piperazin-1-yl)-5,7-dimethylquinoline-3-carbonitrile 
• 1356485-91-0 2-(4-(4-methoxybenzoyl)piperazin-1-yl)-5,7-dimethylquinoline-3-carbonitrile 
• 1356485-95-4 N-(3-(3-cyano-5,7-dimethylquinolin-2-ylamino)propyl)-2-methoxybenzamide 
• 1356485-96-5 N-(3-(3-cyano-5,7-dimethylquinolin-2-ylamino)propyl)-3-methoxybenzamide 
• 1356485-97-6 N-(3-(3-cyano-5,7-dimethylquinolin-2-ylamino)propyl)-4-methoxybenzamide 
• 917747-10-5 2-chloro-5,7-dimethylquinoline-3-carbonitrile 

Relevant academic research and scientific papers

Synthesis of new 3-(2-Chloroquinolin-3-yl)-5-phenylisoxazole derivatives via click chemistry approach

Herein, we report the synthesis of new substituted 3-(2-chloroquinolin-3- yl)-5-phenylisoxazole (3a-j) by click chemistry in good to moderate yields. This approach is based on the regioselective copper(I)-catalyzed cycloaddition between different nitrile oxides derived from 2-chloroquinoline- 3-carbaldehyde (2a-j) and phenylacetylene. Finally these derivatives were screened for their antibacterial evaluation in vitro against three Gram-negative clinical bacteria: Escherichia coli, Pseudomonas aeruginosa and Acinetobacter baumannii using standard methods.

Structure-activity relationships of cyanoquinolines with corrector-potentiator activity in Δf508 cystic fibrosis transmembrane conductance regulator protein

Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. The most common CF-causing mutation, ΔF508-CFTR, produces CFTR loss-of-function by impairing its cellular targeting to the plas