1356549-93-3Relevant academic research and scientific papers
Lead optimization of 2-(piperidin-3-yl)-1H-benzimidazoles: Identification of 2-morpholin- and 2-thiomorpholin-2-yl-1H-benzimidazoles as selective and CNS penetrating H1-antihistamines for insomnia
Ravula, Satheesh Babu,Yu, Jinghua,Tran, Joe A.,Arellano, Melissa,Tucci, Fabio C.,Moree, Wilna J.,Li, Bin-Feng,Petroski, Robert E.,Wen, Jianyun,Malany, Siobhan,Hoare, Samuel R.J.,Madan, Ajay,Crowe, Paul D.,Beaton, Graham
, p. 421 - 426 (2012/02/04)
The structure-activity relationships of 2-(piperidin-3-yl)-1H- benzimidazoles, 2-morpholine and 2-thiomorpholin-2-yl-1H-benzimidazoles are described. In the lead optimization process, the pKa and/or log P of benzimidazole analogs were reduced e
