1356571-60-2Relevant academic research and scientific papers
Effect of capping groups at the N- and C-termini on the conformational preference of α,β-peptoids
De Santis, Emiliana,Hjelmgaard, Thomas,Caumes, Cecile,Faure, Sophie,Alexander, Bruce D.,Holder, Simon J.,Siligardi, Giuliano,Taillefumier, Claude,Edwards, Alison A.
, p. 1108 - 1122 (2012/04/10)
A study was conducted to investigate the effect of capping groups at the N- and C-termini on the conformational preference of α, β-peptoids. Capping groups were carefully selected to minimize their influence on the peptoid secondary structure, such as through H-bonding. The effect of protecting group strategy for peptoids was important to consider when investigating conformational preference. The study focused on N spe α, β-peptoids and revealed that the phenylethyl side chain was found to promote helical secondary structure for α-peptoids on the basis of a combination of NMR, molecular modeling, and CD studies. This side chain was selected to facilitate interpretation of results and comparison to CD data of α and β-peptoid homologues.
