1356585-03-9

Basic information

• Product Name: 2,4-bis(4-methoxyphenyl)oxazol-5(4H)-one
• Synonyms: 2,4-bis(4-methoxyphenyl)oxazol-5(4H)-one
• CAS NO: 1356585-03-9
• Molecular Weight: 297.31
• Mol File: 1356585-03-9.mol

Chemical Properties

• CAS DataBase Reference: 2,4-bis(4-methoxyphenyl)oxazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-bis(4-methoxyphenyl)oxazol-5(4H)-one(1356585-03-9)
• EPA Substance Registry System: 2,4-bis(4-methoxyphenyl)oxazol-5(4H)-one(1356585-03-9)

Safety Data

• Hazardous Substances Data: 1356585-03-9(Hazardous Substances Data)

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 74273-47-5 methyl 2-amino-2-(4-methoxyphenyl)acetate 

Downstream Products

• 1356584-76-3 (2S,3S)-methyl 2-(4-methoxybenzamido)-3-(1-benzyl-1H-indol-3-yl)-2-(4-methoxyphenyl)butanoate 

Relevant articles and documents

Catalytic Aerobic Cross-Dehydrogenative Coupling of Azlactones en Route to α,α-Disubstituted α-Amino Acids

We developed a catalytic aerobic method to synthesize α,α-disubstituted α-amino acids through cross-dehydrogenative coupling of azlactones. Combining an iron catalyst with a bisoxazolidine ligand resulted in high catalytic performance, and cross-coupling with an indole proceeded smoothly under aerobic conditions. A wide variety of α-aryl and aliphatic amino acid derived azlactones were applied to the present catalysis. In addition, a quaternary carbon could be constructed using oxindole and benzofuranone under aerobic conditions.

Strategy for Catalytic Chemoselective Cross-Enolate Coupling Reaction via a Transient Homocoupling Dimer

A new strategy, a transient homocoupling dimer strategy, for direct catalytic oxidative cross-enolate coupling reactions is developed. Cross-enolate coupling products bearing a (contiguous) tetrasubstituted carbon center were obtained chemoselectively without the need for stoichiometric amounts of strong bases/metal oxidants, and thus, the present catalysis provides a general method for the synthesis of unnatural α,α-disubstituted amino acid motifs. The distinct transformation of azlactone and 2-acylimidazole units highlighted the synthetic utility of the present catalysis.