13566-66-0Relevant academic research and scientific papers
ALKYLATION OF 1,3-DIMETHYLBARBITURIC ACID BY ALKYL IODIDES
Krasnov, K. A.,Slesarev, V. I.,Artem'eva, Z. L.
, p. 1402 - 1405 (2007/10/02)
The alkylation of 1,3-dimethylbarbituric acid by methyl iodide, ethyl iodide, and isopropyl iodide in the presence of triethylamine was investigated.The kinetics of the process were studied, and it was shown that the steric and electronic factors affect the rate of the alkylation reactions.Only the products from alkylation at the C5 atom are formed in the case of methyl iodide, and concurrent alkylation at the C5 and O4(6) atoms is observed with ethyl iodide and isopropyl iodide.
