1356600-58-2

Upstream product

• 1255212-83-9 (2R,5R,6S)-tert-Butyl-2-(tert-butyldimethylsilyloxy)-4-(1-(4-methoxybenzyloxy)propan-2-ylamino)-3-methylbutyl(methyl)carbamate 
• 1356600-53-7 C₂₁H₃₀FN₃O₇ 
• 1356600-45-7 C₂₇H₄₄N₂O₇ 

Relevant academic research and scientific papers

Build/couple/pair strategy for the synthesis of stereochemically diverse macrolactams via head-to-tail cyclization

A build/couple/pair (B/C/P) strategy was employed to generate a library of 7936 stereochemically diverse 12-membered macrolactams. All 8 stereoisomers of a common linear amine precursor were elaborated to form the corresponding 8 stereoisomers of two regioisomeric macrocyclic scaffolds via head-to-tail cyclization. Subsequently, these 16 scaffolds were further diversified via capping of two amine functionalities on SynPhase Lanterns. Reagents used for solid-phase diversification were selected using a sparse matrix design strategy with the aim of maximizing coverage of chemical space while adhering to a preset range of physicochemical properties.