135679-88-8

Basic information

• Product Name: Glycyl-L-prolyl-L-arginyl-L-prolyl-L-alaninamide
• Synonyms: Glycyl-L-prolyl-L-arginyl-L-prolyl-L-alaninamide;Vialox;Vialox Peptide / Pentapeptide-3;Vialox, Pentapeptide-3;Pentapeptide-3/Vialox Peptide
• CAS NO: 135679-88-8
• Molecular Formula: C21H37N9O5
• Molecular Weight: 495.58
• Mol File: 135679-88-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.54
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 13.59±0.20(Predicted)
• CAS DataBase Reference: Glycyl-L-prolyl-L-arginyl-L-prolyl-L-alaninamide(CAS DataBase Reference)
• NIST Chemistry Reference: Glycyl-L-prolyl-L-arginyl-L-prolyl-L-alaninamide(135679-88-8)
• EPA Substance Registry System: Glycyl-L-prolyl-L-arginyl-L-prolyl-L-alaninamide(135679-88-8)

Safety Data

• Hazardous Substances Data: 135679-88-8(Hazardous Substances Data)

Usage

Benifits for skin

Vialox, or Pentapeptide-3, is a synthetic peptide that acts on a different part of the neuromuscular junction. As a competitive antagonist at nicotinic acetylcholine receptors, Vialox prevents the sodium influx required for muscle fibers to depolarize and contract. Within one minute of treatment, muscle contracts can be reduced by up to 71%, and 58% of muscle fibers are still immotile two hours later. Vialox can prevent wrinkles from getting deeper due to muscle contractions. In one study, Vialox used twice a day for 28 days resulted in a nearly 50% reduction in wrinkle depth and roughness. It can be used at concentrations of 0.05%–0.3% to treat facial wrinkles and tighten skin.

Relevant articles and documents

Sustainable Peptide Synthesis Enabled by a Transient Protecting Group

The growing interest in synthetic peptides has prompted the development of viable methods for their sustainable production. Currently, large amounts of toxic solvents are required for peptide assembly from protected building blocks, and switching to water as a reaction medium remains a major hurdle in peptide chemistry. We report an aqueous solid-phase peptide synthesis strategy that is based on a water-compatible 2,7-disulfo-9-fluorenylmethoxycarbonyl (Smoc) protecting group. This approach enables peptide assembly under aqueous conditions, real-time monitoring of building block coupling, and efficient postsynthetic purification. The procedure for the synthesis of all natural and several non-natural Smoc-protected amino acids is described, as well as the assembly of 22 peptide sequences and the fundamental issues of SPPS, including the protecting group strategy, coupling and cleavage efficiency, stability under aqueous conditions, and crucial side reactions.