1356829-41-8Relevant articles and documents
Quinolinone-based agonists of S1P1: Use of a N-scan SAR strategy to optimize in vitro and in vivo activity
Pennington, Lewis D.,Croghan, Michael D.,Sham, Kelvin K.C.,Pickrell, Alexander J.,Harrington, Paul E.,Frohn, Michael J.,Lanman, Brian A.,Reed, Anthony B.,Lee, Matthew R.,Xu, Han,McElvain, Michele,Xu, Yang,Zhang, Xuxia,Fiorino, Michael,Horner, Michelle,Morrison, Henry G.,Arnett, Heather A.,Fotsch, Christopher,Tasker, Andrew S.,Wong, Min,Cee, Victor J.
, p. 527 - 531 (2012)
We reveal how a N-scan SAR strategy (systematic substitution of each CH group with a N atom) was employed for quinolinone-based S1P1 agonist 5 to modulate physicochemical properties and optimize in vitro and in vivo activity. The diaza-analog 1
