1356832-77-3Relevant academic research and scientific papers
Rhodium catalyzed C-H olefination of N-benzoylsulfonamides with internal alkenes
Zhu, Chen,Falck, John R.
supporting information; experimental part, p. 1674 - 1676 (2012/03/11)
An annulation via tandem rhodium catalyzed C-H olefination of N-benzoylsulfonamides with internal olefins followed by C-N bond formation is disclosed. A N-substituted quaternary center is formed during the reaction thus providing efficient access to a series of 3,3-disubstituted isoindolinones. The Royal Society of Chemistry 2012.
Rhodium catalyzed synthesis of isoindolinones via C-H activation of N-benzoylsulfonamides
Zhu, Chen,Falck, John R.
, p. 9192 - 9199 (2012/10/29)
An efficient approach to a wide range of isoindolinones, including 3-monosubstituted and 3,3-disubstituted isoindolinones, from the annulation of N-benzoylsulfonamides with olefins and diazoacetate has been developed. The transformation is broadly compatible with both terminal and internal olefins. Moreover, diazoacetate is for the first time incorporated into an amide-directed C-H functionalization reaction. Specifically, the rhodium complex [{RhCl 2Cp*}2] enables the in situ dimerization of diazoacetate in addition to its role in catalyzing C-H functionalization/cross- coupling.
