1356964-76-5Relevant academic research and scientific papers
Cross-metathesis of allyl halides with olefins bearing amide and ester groups
Yun, Jeong In,Kim, Hyoung Rae,Kim, Sang Kyum,Kim, Deukjoon,Lee, Jongkook
, p. 1177 - 1184 (2012)
An investigation was conducted to determine whether the cross-metathesis (CM) of allyl halides tolerates amide groups. The results show that the ruthenium-based complexes I-III serve as poor catalysts for the CM of allyl halides with olefins that contain an N,N-dimethylamide group. In contrast, the Grubbs-Hoveyda-Blechert second generation catalyst (III) efficiently promotes these processes with olefins bearing a Weinreb amide group. Lastly, a reinvestigation of the ester group tolerance of the allyl halide CM with unsaturated esters demonstrated that III serves as an efficient catalyst for these reactions.
