1356998-41-8 Usage
Description
(4-iodo-2,5-dimethylpyrazol-3-yl)methanol is a chemical compound with the molecular formula C8H10IN2O, derived from pyrazole and featuring an iodine atom attached to the 4th position of the pyrazole ring along with a hydroxyl group, making it a primary alcohol. (4-iodo-2,5-dimethylpyrazol-3-yl)methanol holds potential in medicinal chemistry, drug development, organic synthesis, and as a building block for other chemical compounds.
Uses
Used in Medicinal Chemistry:
(4-iodo-2,5-dimethylpyrazol-3-yl)methanol is used as a chemical intermediate for the synthesis of various pharmaceutical compounds due to its unique structural features and reactivity.
Used in Drug Development:
In the pharmaceutical industry, (4-iodo-2,5-dimethylpyrazol-3-yl)methanol is used as a key component in the development of new drugs, leveraging its structural properties to create novel therapeutic agents.
Used in Organic Synthesis:
(4-iodo-2,5-dimethylpyrazol-3-yl)methanol serves as a valuable building block in organic synthesis, contributing to the creation of a wide range of chemical products.
Used as a Laboratory Reagent:
In a laboratory setting, (4-iodo-2,5-dimethylpyrazol-3-yl)methanol is used as a reagent for various chemical reactions, taking advantage of its functional groups and reactivity.
It is important to handle (4-iodo-2,5-dimethylpyrazol-3-yl)methanol with care and follow proper safety precautions when working with it in a laboratory setting.
Check Digit Verification of cas no
The CAS Registry Mumber 1356998-41-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,6,9,9 and 8 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1356998-41:
(9*1)+(8*3)+(7*5)+(6*6)+(5*9)+(4*9)+(3*8)+(2*4)+(1*1)=218
218 % 10 = 8
So 1356998-41-8 is a valid CAS Registry Number.
1356998-41-8Relevant articles and documents
Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity
Bruncko, Milan,Wang, Le,Sheppard, George S.,Phillips, Darren C.,Tahir, Stephen K.,Xue, John,Erickson, Scott,Fidanze, Steve,Fry, Elizabeth,Hasvold, Lisa,Jenkins, Gary J.,Jin, Sha,Judge, Russell A.,Kovar, Peter J.,Madar, David,Nimmer, Paul,Park, Chang,Petros, Andrew M.,Rosenberg, Saul H.,Smith, Morey L.,Song, Xiaohong,Sun, Chaohong,Tao, Zhi-Fu,Wang, Xilu,Xiao, Yu,Zhang, Haichao,Tse, Chris,Leverson, Joel D.,Elmore, Steven W.,Souers, Andrew J.
, p. 2180 - 2194 (2015/03/30)
Myeloid cell leukemia 1 (MCL-1) is a BCL-2 family protein that has been implicated in the progression and survival of multiple tumor types. Herein we report a series of MCL-1 inhibitors that emanated from a high throughput screening (HTS) hit and progressed via iterative cycles of structure-guided design. Advanced compounds from this series exhibited subnanomolar affinity for MCL-1 and excellent selectivity over other BCL-2 family proteins as well as multiple kinases and GPCRs. In a MCL-1 dependent human tumor cell line, administration of compound 30b rapidly induced caspase activation with associated loss in cell viability. The small molecules described herein thus comprise effective tools for studying MCL-1 biology.
