135702-93-1Relevant academic research and scientific papers
A General and Simple Synthesis of α-Halo Amides via α,α-Dicyano Epoxides
Pironnec, Marie-Gabrielle Le,Guinamant, Jean-Luc,Robert, Albert,Baudy-Floc'h, Michele
, p. 229 - 232 (2007/10/03)
A one-pot reaction of α,α-dicyano epoxides with amine hydrohalides provides an attractive and general route to α-halo amides.A wide variety of amines (primary alkyl, aryl, amino esters, amino amides) and epoxides (monosubstituted alkyl, aryl: disubstitute
Opening of gem dicyano epoxides with amino hydrohalides: Application to the synthesis of structural analogs of tetramisole and biological evaluation
Jaguelin,Robert,Genetet,Gayral
, p. 313 - 321 (2007/10/02)
α-halogenamides are prepared in a onepot reaction by reacting gem dicyano epoxides with amino hydrohalides. This original reactivity of gem dicyano epoxides is used to prepare substituted [2,1-b]imidazothiazoles which are structural analogs of tetramisole
