1357027-87-2Relevant academic research and scientific papers
Helix-helix interactions - Homochirality and heterochirality
Stefankiewicz, Artur R.,De Cian, Andre,Harrowfield, Jack
, p. 7207 - 7211 (2011)
The relatively simple molecule 2-amino-4-(thiazolin-2-yl)phenol, 1, as its acetonitrile solvate crystallises such that the lattice can be considered to contain heterochiral sheets of helical, N...HO H-bonded polymers which are linked within their sheets by weaker N...HN H-bonds between adjacent helices of opposite chirality. Weaker interactions of the CH...π type can be discerned as linking helices of the same chirality between these sheets, these interactions being reinforced by weaker interactions still involving the acetonitrile solvent molecules. A similar analysis can be conducted of the helical structures found within the lattice of the related compound 4-(methoxycarbonyl)-2-aminophenol, 2, although here it is more difficult to define the hierarchy of the weak interactions observed.
