135704-06-2

Usage

Uses

Used in Pharmaceutical Industry:
CI 992 is used as an antihypertensive agent for its ability to effectively control blood pressure in both normotensive and hypertensive subjects. Its oral activity and potency make it a promising candidate for the development of new treatments for hypertension.
Used in Cardiovascular Research:
CI 992 is used as a research tool for studying the role of renin in blood pressure regulation and the development of hypertension. Its effectiveness in managing blood pressure can provide valuable insights into the underlying mechanisms of hypertension and contribute to the development of new therapeutic strategies.
Used in Drug Development:
CI 992 is used as a lead compound in the development of new antihypertensive drugs. Its potent renin-inhibiting properties and oral activity make it a valuable starting point for the design and synthesis of novel therapeutic agents targeting hypertension and related cardiovascular conditions.

InChI:InChI=1/C33H52N6O7S2/c1-22(2)17-29(40)30(41)26(18-23-9-5-3-6-10-23)36-27(20-25-21-47-33(34)35-25)31(42)37-32(43)28(19-24-11-7-4-8-12-24)38-48(44,45)39-13-15-46-16-14-39/h4,7-8,11-12,21-23,26-30,36,38,40-41H,3,5-6,9-10,13-20H2,1-2H3,(H2,34,35)(H,37,42,43)/t26-,27-,28-,29-,30+/m0/s1

Upstream product

• 135727-10-5 <1S-(1R*,2S*,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-<2-<<(phenylmethoxy)carbonyl>amino>-4-thiazolyl>-L-alaninamide 
• 135704-30-2 (S)-3-(2-Amino-thiazol-4-yl)-2-tert-butoxycarbonylamino-propionic acid benzyl ester 
• 135704-24-4 N-<(1,1-dimethylethoxy)carbonyl>-3-<2-<<(phenylmethoxy)carbonyl>amino>-4-thiazolyl>-L-alanine 
• 135703-72-9 {4-[(S)-2-Amino-2-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-ethyl]-thiazol-2-yl}-carbamic acid benzyl ester 
• 150114-17-3 phenylmethyl N-<(1,1-dimethylethoxy)carbonyl>-3-<2-<<(phenylmethoxy)carbonyl>amino>-4-thiazolyl>-L-alaninate 
• 135760-03-1 phenylmethyl <1S-<1R*(R*),2S*,3R*>>-<4-<3-<<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>amino>-2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-oxopropyl>-2-thiazolyl>carbamate 
• 135703-88-7 2,2,2-trichloroethyl <1S-<1R*(R*),2S*,3R*>>-<4-<3-<<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>amino>-2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-oxopropyl>-2-thiazolyl>carbamate 
• 135703-86-5 phenylmethyl N-<(1,1-dimethylethoxy)carbonyl>-3-<2-<<(2,2,2-trichloroethoxy)carbonyl>amino>-4-thiazolyl>-L-alaninate 
• 135703-87-6 (S)-2-tert-Butoxycarbonylamino-3-[2-(2,2,2-trichloro-ethoxycarbonylamino)-thiazol-4-yl]-propionic acid 
• 122621-77-6 (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane 
• 135704-12-0 <1S-(1R*,2S*,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-<2-<<(2,2,2-trichloroethoxy)carbonyl>amino>-4-thiazolyl>-L-alaninamide 

Relevant academic research and scientific papers

Structure-Activity Relationships of a Series of 2-Amino-4-thiazole-Containing Renin Inhibitors

A series of renin inhibitors was synthesized that contained a 2-amino-4-thiazolyl moiety at the P2 position.These derivatives are potent inhibitors of monkey renin in vitro and are selective in that they only weakly inhibit the closely related