1357192-71-2

Upstream product

• 1357192-19-8 1-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-propan-2-ol 
• 1126-00-7 1-phenylpyrazole 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 1357192-20-1 1-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)propan-2-one 
• 1357192-73-4 5-amino-1-cyclobutyl-4-fluoro-3,3-dimethyl-1,3-dihydro-2H-indol-2-one 
• 1357192-72-3 1-cyclobutyl-4-fluoro-3,3-dimethyl-5-nitro-1,3-dihydro-2H-indol-2-one 
• 1357192-10-9 4-fluoro-3,3-dimethyl-5-nitro-1,3-dihydro-2H-indol-2-one 
• 866211-50-9 4-fluoro-3,3-dimethyl-1,3-dihydro-2H-indol-2-one 

Relevant academic research and scientific papers

Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor

Highly potent and brain-penetrant phosphodiesterase 10A (PDE10A) inhibitors based on the 2-oxindole scaffold were designed and synthesized. (2-Oxo-1,3-oxazolidin-3-yl)phenyl derivative 1 showed the high P-glycoprotein (P-gp) efflux (efflux ratio (ER) = 6.

HETEROCYCLIC COMPOUND

The present invention provides a compound represented by the formula (1): wherein each symbol is as defined in the specification, or a salt thereof, a prodrug of the compound or a salt thereof, a medicament containing the compound or a salt thereof, the medicament which is a phosphodiesterase 10A inhibitor, and a medicament which is for preventing or treating schizophrenia.