1357195-04-0Relevant articles and documents
CONJUGATE BASED SYSTEMS FOR CONTROLLED INSULIN DELIVERY
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Page/Page column 79, (2019/07/13)
The present disclosure provides conjugates that comprise an insulin molecule conjugated via a conjugate framework to two or more separate ligands that each include a saccharide, wherein the framework, ligand, saccharide and insulin molecule optionally com
GLUCOSE-RESPONSIVE INSULIN CONJUGATES
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Paragraph 0379, (2015/04/21)
Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein the saccharide for at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.
