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135729-62-3

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Product FOB Price Min.Order Supply Ability Supplier
Palonosetron Hydrochloride
Cas No: 135729-62-3
No Data 1 Kilogram 2000 Metric Ton/Year Hunan Longxianng Runhui Trading Co.,Ltd Contact Supplier
Palonosetron HCl CAS:135729-62-3
Cas No: 135729-62-3
No Data 1 Gram 1-100 Metric Ton/Month Hangzhou Hysen Pharma co.,Ltd. Contact Supplier
Palonosetron Hydrochloride
Cas No: 135729-62-3
No Data 1 Kilogram inquiry by mail Kilogram/Year Chengdu Sino-Strong Pharmaceutical Co.,Ltd. Contact Supplier
High quality Palonosetron Hydrochloride
Cas No: 135729-62-3
No Data 1 Gram 10 Gram/Week Qingdao Xinnuo pharmaceutical Chemical Co.,Ltd Contact Supplier
Palonosetron hydrochloride
Cas No: 135729-62-3
No Data No Data No Data Hunan chemfish Pharmaceutical co.,Ltd Contact Supplier
Palonosetron HCl
Cas No: 135729-62-3
No Data No Data 100 Kilogram/Year Koning Pharmchem Co., Ltd. Contact Supplier
High quality Palonosetron Hcl supplier in China
Cas No: 135729-62-3
No Data No Data No Data Simagchem Corporation Contact Supplier
Palonosetron hydrochloride Manufacturer/High quality/Best price/In stock
Cas No: 135729-62-3
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Hangzhou Dayangchem Co., Ltd. Contact Supplier
Palonosetron Hydrochloride
Cas No: 135729-62-3
No Data 1 Kilogram 200 Kilogram/Month HENAN SUNLAKE ENTERPRISE CORPORATION Contact Supplier
Factory USP/EP Palonosetron HCl in stock CAS 135729-62-3
Cas No: 135729-62-3
No Data 1 Gram 1 Metric Ton/Month Shaanxi Mingqi Chemical Co., Ltd Contact Supplier

135729-62-3 Usage

Uses

Palonosetron HCl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting

Definition

ChEBI: A hydrochloride obtained by combining palonosetron with one molar equivalent of hydrogen chloride; an antiemetic used in combination with netupitant (under the trade name Akynzeo) to treat nausea and vomiting in patients undergoing cancer chemotherapy.

Brand name

Aloxi (Helsinn).

Adverse effects

The most common adverse effects are headache, which occurs in 4–11% of patients, and constipation in up to 6% of patients. In less than 1% of patients, other gastrointestinal disorders occur, as well as sleeplessness, first-and second-degree atrioventricular block, muscle pain and shortness of breath. Palonosetron is similarly well tolerated as other setrons, and slightly less than placebo.

Uses

Serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.

Uses

specifically inhibits cells of the adrenal cortex and their production of hormones for adrenocortical tumor therapy, causes CNS damage, but no bone marrow depression.

Nausea and vomiting drug

Palonosetron hydrochloride is a drug to inhibit nausea and vomiting, which is a new type highly selective, high-affinity 5-HT3 receptor antagonist that can block the vomiting reflex center peripheral neurons presynaptic 5-HT. Receptor excitement directly affects the central nervous system in 5-HT. Impulse receptor excitement generated by the role of vagal afferent nerve after area, blocking the vagus nerve endings in the gut, preventing signals to 5-HT. Receptor trigger zone can reduce the incidence of nausea and vomiting. Central clinically for the treatment of acute severe emetogenic chemotherapy induced delayed nausea and vomiting. Because of its high curative effect, little side effect, long half-life (about 40 h), small dosage, and so on, it has attracted much attention.
With 1,2,3,4-tetrahydro-1-naphthoic acid as the starting material, the split, amination, reduction, cyclization, salt of palonosetron hydrochloride granisetron.
Clinical studies showed that palonosetron can be used safely with corticosteroids, analgesics, antiemetics, antispasmodics and anticholinergic drugsas the starting material, the split, amination, reduction, cyclization, salt of palonosetron hydrochloride granisetron.
Murine tumor model studies indicate that palonosetron does not inhibit the five kinds of chemotherapy drugs studied (cisplatin, cyclophosphamide, cytarabine, doxorubicin and mitomycin C) anti-cancer activity.

References

https://en.wikipedia.org/wiki/Palonosetron

Uses

Palonosetron is a potent, selective antagonist of the serotonin (5-HT) receptor 5-HT3 (pKi = 10.4 in rat cortex) that minimally effects a wide range of other neuronal receptors. It is orally bioavailable and potently inhibits emesis induced by chemotherapeutic drugs, like cisplatin , but not by apomorphine , which acts by dopamine receptor antagonism. Palonosetron is remarkable for its long duration of action, related to its high receptor-binding affinity and long half-life. It is effective in managing chemotherapy-induced nausea and vomiting.[Cayman Chemical]

Chemical Properties

White Solid
InChI:InChI=1/C19H24N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,13,15,17H,1,3,5,7-12H2;1H/t15-,17-;/m1./s1

135729-62-3 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma (SML1195)  Palonosetron hydrochloride  ≥98% (HPLC) 135729-62-3 SML1195-50MG 4,469.40CNY Detail
Sigma (SML1195)  Palonosetron hydrochloride  ≥98% (HPLC) 135729-62-3 SML1195-10MG 1,107.99CNY Detail
USP (1492200)  Palonosetron hydrochloride  United States Pharmacopeia (USP) Reference Standard 135729-62-3 1492200-100MG 4,647.24CNY Detail
TCI America (P2051)  Palonosetron Hydrochloride  >98.0%(HPLC)(T) 135729-62-3 1g 3,950.00CNY Detail
TCI America (P2051)  Palonosetron Hydrochloride  >98.0%(HPLC)(T) 135729-62-3 200mg 1,150.00CNY Detail

135729-62-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name palonosetron hydrochloride

1.2 Other means of identification

Product number -
Other names (3aS)-2-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-3a,4,5,6-tetrahydro-3H-benzo[de]isoquinolin-1-one,hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:135729-62-3 SDS

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