1357291-95-2Relevant academic research and scientific papers
N6-Substituted adenosines. Cytokinin and antitumor activities
Kolyachkina, Svetlana V.,Tararov, Vitali I.,Alexeev, Cyril S.,Krivosheev, Dmitry M.,Romanov, Georgy A.,Stepanova, Evgenia V.,Solomko, Eliso S.,Inshakov, Andrey N.,Mikhailov, Sergey N.
, p. 1361 - 1378 (2011)
A series of N6-adenosine derivatives were synthesized by alkylation of N6-acetyl-2',3',5'-tri-O-acetyladenosine (1) with alkyl halides and alcohols. It was shown that propargyl derivative 2a is a good substrate for copper(I) catalyzed Huisgen [3+2] cycloaddition with azides. This click-reaction can be used for preparation of the libraries of 1,2,3-triazolyl modified adenosines. Biological activities of N6-adenosines were studied in two plant and six human cancer cell assays. The remarkable parallel between cytokinin and cytotoxic activities was found. The most cytokinin active compounds 3c-3e at the same time appeared to be the most potent cytotoxic agents.
