135734-97-3Relevant academic research and scientific papers
Novel antioxidants’ synthesis and their anti-oxidative activity through activating Nrf2 signaling pathway
Wu, Jianzhang,Ren, Jiye,Yao, Song,Wang, Jiabing,Huang, Lili,Zhou, Peng,Yun, Di,Xu, Qing,Wu, Shoubiao,Wang, Zhankun,Qiu, Peihong
, p. 1616 - 1619 (2017)
Novel structure compounds (WS) containing 3,4,5-trimethoxyphenyl and acyl pyrazole were designed and synthesized based combination principles. Among them, WS13 was screened out to possess desirable anti-oxidative activity in vitro. Cell survival assay and apoptosis experiment in H2O2 induced PC12 cells injury model all showed that its cytoprotection exhibited a concentration-effect manner. WS13 at 10?μM could remove ROS with equal effiency to edaravone. Further, it clearly activated Nrf2 nuclear translocation and upregulated GCLC mRNA transcription and protein expression in dose-dependent manner, and its cytoprotection was reversed by GCLC protein inhibitor. In total, WS13 with further promotion can serve as Nrf2-GCLC activator in anti-oxidative therapy.
A 3, 4, 5 - trimethoxy compounds and in the application of the drug in the preparation of antioxidant (by machine translation)
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Paragraph 0021; 0022, (2017/09/02)
The invention belongs to the field of pharmaceutical chemistry, and in particular relates to a 3, 4, 5 - trimethoxy compounds and their application in preparing antioxidant medicine, this novel antioxidant 3, 4, 5 - trimethoxy compounds can activate the Nrf2 signal path, upward path downstream related protein GCLC expression, and then removing the intracellular free radical ROS, thus to H2 O2 Induced PC12 cell injury protection role. (by machine translation)
2-METHYLENE-5-SUBSTITUTED-METHYLENECYCLOPENTANONE DERIVATIVES AND USE THEREOF
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Page/Page column 11, (2011/04/18)
The invention relates to 2-methylene-5-substituted-methylenecyclopentanone derivatives of formula I, and the use thereof. The derivatives of formula I as active components are useful for preparing a medicine for the treatment and/or prevention of cancer diseases such as breast cancer, lung cancer, colon cancer, rectal cancer, stomach cancer, prostate cancer, bladder cancer, uterus cancer, pancreatic cancer and ovary cancer. The active compounds of the invention may be used as an anticancer drug alone or used in combination with one or more other antitumor drugs. A combined therapy can be carried out by administrating each therapeutic component concurrently, subsequently or separately.
2-METHYLENE-5-SUBSTITUTED METHYLENE CYCLOPENTANONE DERIVATIVES AND USE THEREOF
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Page/Page column 15, (2010/11/19)
The invention relates to 2-methylene-5-substituted-methylenecyclopentanone derivatives of formula I, and the use thereof. The derivatives of formula I as active components are useful for preparing a medicine for the treatment and/or prevention of cancer diseases such as breast cancer, lung cancer, colon cancer, rectal cancer, stomach cancer, prostate cancer, bladder cancer, uterus cancer, pancreatic cancer and ovary cancer. The active compounds of the invention may be used as an anticancer drug alone or used in combination with one or more other antitumor drugs. A combined therapy can be carried out by administrating each therapeutic component concurrently, subsequently or separately.
