1357389-11-7 Usage
Description
RGFP966 (1357389-11-7) is a selective inhibitor of HDAC3 (IC50?= 80 nM, no other HDACs inhibited @ 15μM).1?It facilitates the extinction of cocaine-seeking behavior in mice and transforms subthreshold learning events into robust long-term memory, suggesting a potential therapeutic target for memory enhancement and neurodegenerative diseases.1-5
Uses
(E)-RGFP 966 is a histone deacetylase 3 (HDAC3) inhibitor.
References
1) Malvaez?et al.?(2013),?HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner; Proc. Natl. Acad. Sci. USA?110?2647
2) Bieszczad?et al.?(2015),?Histone Deacetylase Inhibition via RGFP966 Releases the Brakes on Sensory Cortical Plasticity and the Specificity of Memory Formation; J. Neurosci.?35?13124
3) Zhu?et al.?(2017),?HDAC3 negatively regulates spatial memory in a mouse model of Alzheimer’s disease; Aging Cell?16?1073
4) Haiqun?et al. (2016),?The Effects of Pharmacological Inhibition of Histone Deacetylase 3 (HDAC3)in Huntington’s Disease Mice; PLoS One 0152498
5) Janczura?et al.?(2018),?Inhibition of HDAC3 reverses Alzheimer’s disease-related pathologies in vitro and in the 3xTg-AD mouse model; Proc. Natl. Acad. Sci. USA?115?E11148
Check Digit Verification of cas no
The CAS Registry Mumber 1357389-11-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,7,3,8 and 9 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1357389-11:
(9*1)+(8*3)+(7*5)+(6*7)+(5*3)+(4*8)+(3*9)+(2*1)+(1*1)=187
187 % 10 = 7
So 1357389-11-7 is a valid CAS Registry Number.
