13574-14-6

Basic information

• Product Name: N,N,N~2~,N~2~-tetramethylglycinamide
• Synonyms: Acetamide, 2- (dimethylamino)-N,N-dimethyl-; acetamide, 2-(dimethylamino)-N,N-dimethyl-; N,N,N~2~,N~2~-Tetramethylglycinamide
• CAS NO: 13574-14-6
• Molecular Formula: C₆H₁₄N₂O
• Molecular Weight: 130.1882
• Mol File: 13574-14-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 174.7°C at 760 mmHg
• Flash Point: 55.8°C
• Density: 0.935g/cm³
• Vapor Pressure: 1.19mmHg at 25°C
• Refractive Index: 1.448
• CAS DataBase Reference: N,N,N~2~,N~2~-tetramethylglycinamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N,N~2~,N~2~-tetramethylglycinamide(13574-14-6)
• EPA Substance Registry System: N,N,N~2~,N~2~-tetramethylglycinamide(13574-14-6)

Safety Data

• Hazardous Substances Data: 13574-14-6(Hazardous Substances Data)

Usage

General Description

N,N,N~2~,N~2~-tetramethylglycinamide, also known as TMG, is a chemical compound used as a co-solvent in the formulation of electrolytes and as a solubilizing agent for poorly water-soluble drugs. It is a tertiary amine and a derivative of glycine, with four methyl groups attached to the nitrogen atom. TMG is also known for its chaotropic properties, which disrupt the structure of biological macromolecules, and for its ability to stabilize proteins and peptides. Additionally, it is used in the synthesis of pharmaceuticals and in the production of various chemical reactions as a catalyst or stabilizing agent. Overall, N,N,N~2~,N~2~-tetramethylglycinamide has a range of applications in chemical and pharmaceutical industries due to its solubility and stabilizing properties.

Upstream product

• 102990-48-7 Benzyl-dimethylcarbamoylmethyl-dimethyl-ammonium; chloride 
• 102990-46-5 Dimethylcarbamoylmethyl-dimethyl-prop-2-ynyl-ammonium; bromide 
• 102990-43-2 Allyl-dimethylcarbamoylmethyl-dimethyl-ammonium; bromide 

Downstream Products

• 15722-62-0 N-Methyl-sarkosin-trimethylamid-Kation 
• 25108-90-1 2,6-Dichloro-4-nitro-phenol; compound with 2-dimethylamino-N,N-dimethyl-acetamide 
• 80354-58-1 2-(dimethylamino)-1-(p-tolyl)ethan-1-one 
• 3319-03-7 2-dimethylamino-1-phenyl-ethanone 
• 857618-57-6 2-dimethylamino-1-(2,5-dimethyl-phenyl)-ethanone 
• 873377-40-3 2-dimethylamino-1-(2,4-dimethyl-phenyl)-ethanone 

Relevant articles and documents

Amines and ammonium compounds. CXCI. The Stevens rearrangement with the participation of the N,N-dimethylcarbamoylmethyl group

Under the influence of powdered potassium hydroxide in benzene ammonium salts containing a group of the allyl or propargyl type in addition to an N,N-dimethylcarbamoylmethyl group enter smoothly into a Stevens 3,2-rearrangement with the formation of the N,N-dimethylamides of 2-dimethylamino-4-pentenoic and 2-dimethylamino-3,4-pentadienoic acids respectively.The salt, which contains a benzyl group as migrating group, forms a mixture of products from the Stevens and Sommelet rearrangements.The possibility of rearrangement under the influence of sodium in DMSO was demonstrated.