135740-95-3Relevant academic research and scientific papers
Palladium(II)-Assisted Dialkylation and Alkylation/Acylation of Optically Active Ene Carbamates via Trialkylorganostannane Cross-Coupling and Carbonylative Coupling Processes
Masters, John J.,Hegedus, Louis S.,Tamariz, Joaquin
, p. 5666 - 5671 (2007/10/02)
Alkylation of benzyl vinyl carbamate and propene with the anions of diethyl methylmalonate or dimethyl malonate in the presence of palladium(II) chloride, followed by cross-coupling or carbonylative cross-coupling with organostannanes, effected an overall dialkylation or alkylation/acylation of the monoolefin substrate.Complete control of stereochemistry in this palladium(II)-assisted reaction was observed using optically active ene carbamates affording β-amino-unsaturated keto esters in good chemical yields and excellent optical purity.
