1357476-11-9Relevant articles and documents
Copper(II) triflate catalyzed allylic arylation of allylic alcohols: Direct and selective access to C-allylanilines
Chen, Ke,Chen, Houguang Jeremy,Wong, Jonathan,Yang, Jinglei,Pullarkat, Sumod A.
, p. 3882 - 3888 (2014/01/06)
Copper(II) triflate was used as a simple and commercially available catalyst in the direct amination of allylic alcohols with anilines to provide C-allylanilines. A wide range of functional groups were tolerated under the reaction conditions, and the products were obtained regioselectivity without the need of an activator. A detailed mechanistic investigation was undertaken. The efficacy of this protocol was demonstrated in the conversion of the 2-allylanilines into substituted quinolines through an oxidative cycloaddition reaction. All(yl) is good: The direct and selective synthesis of C-allylanilines through Cu(OTf)2-catalyzed (OTf=trifluoromethanesulfonyl) allylic amination involving allylic alcohols and anilines is reported. The reaction can be performed under mild conditions and shows wide functional group tolerance and regioselectivity; the products are obtained in good to high yields. Detailed mechanistic investigations are also discussed. Copyright
