1357481-25-4

Basic information

• Product Name: 1-(2-bromo-4,5-dimethoxybenzyl)-N(a)-methyl-1,2,3,4-tetrahydro-β-carboline
• CAS NO: 1357481-25-4
• Molecular Weight: 415.33
• Mol File: 1357481-25-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-bromo-4,5-dimethoxybenzyl)-N(a)-methyl-1,2,3,4-tetrahydro-β-carboline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-bromo-4,5-dimethoxybenzyl)-N(a)-methyl-1,2,3,4-tetrahydro-β-carboline(1357481-25-4)
• EPA Substance Registry System: 1-(2-bromo-4,5-dimethoxybenzyl)-N(a)-methyl-1,2,3,4-tetrahydro-β-carboline(1357481-25-4)

Safety Data

• Hazardous Substances Data: 1357481-25-4(Hazardous Substances Data)

Upstream product

• 61-49-4 [2-(1H-indol-3-yl)-ethyl]-methylamine 
• 6831-57-8 2-bromo-4,5-dimethoxyphenylacetic acid chloride 
• 1357481-24-3 N(a)-methyl-[2-(3-indolyl)-ethyl]-2-(2-bromo-3,4-dimethoxyphenyl)acetamide 

Relevant articles and documents

Phosphane-free Pd0-catalyzed cycloamination and carbonylation with Pd(OAc)2 and Cu(OAc)2 in the presence of K 2CO3: Preparation of benzocyclic amines and benzolactams

Phosphane-free Pd0-catalyzed intramolecular aromatic amination was studied. o-Halophenethylamines and 3-(o-halophenyl)propylamines were found to be transformed into indolines and quinolines in a catalytic system based on Pd(OAc)2 and Cu(OAc)2 in the presence of K 2CO3. Application of the method to substrates containing isoquinoline rings- the 1-(o-bromobenzyl)-3,4-dihydroisoquinolines 6, the 1-(o-bromobenzyl)-1,2,3,4-tetrahydroisoquinolines 7, and the 1-(o-bromophenethyl)isoquinolines 9- provided the indolo[2,1-a]isoquinoline and dibenzo[a,f]quinolizine ring systems 8 and 10. Extension of the method to β-carbolines (compounds 11, 12, and 17) produced the benz[f]indolo[2,3-a] indolizine-13-ones 15 and the benz[f]indolo[2,3-a]quinolizine 18. The benzo[f]pyrido[3,4-a]indolizine and indolo[f]pyrido[3,4-a]indolizin-12-one ring systems 27 and 31 were built in a similar manner. It was also found that under an atmosphere of CO the same catalytic system produced the corresponding benzolactams, the isoquino[2,1-a][2,7]naphthyridine 34 and the indolo[2,3-a]pyrido[g]quinolizin-8-one 36 [(±)-dihydronauclefine] in good yields. Copyright