1357488-01-7

Basic information

• Product Name: (+)-(2S,3R)-3-(benzyloxycarbonyl)methyl-2-methoxycarbonyl-5-oxopyrrolidine
• CAS NO: 1357488-01-7
• Molecular Weight: 291.304
• Mol File: 1357488-01-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (+)-(2S,3R)-3-(benzyloxycarbonyl)methyl-2-methoxycarbonyl-5-oxopyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-(2S,3R)-3-(benzyloxycarbonyl)methyl-2-methoxycarbonyl-5-oxopyrrolidine(1357488-01-7)
• EPA Substance Registry System: (+)-(2S,3R)-3-(benzyloxycarbonyl)methyl-2-methoxycarbonyl-5-oxopyrrolidine(1357488-01-7)

Safety Data

• Hazardous Substances Data: 1357488-01-7(Hazardous Substances Data)

Upstream product

• 1173452-00-0 (E)-dibenzyl pent-2-enedioate 
• 1357487-91-2 benzyl methyl 2-nitro-3-(benzyloxycarbonyl)methylpentanedioate 
• 628-48-8 glutaconic acid 

Relevant articles and documents

First chemoenzymatic synthesis of (+)-2-carboxypyrrolidine-3-acetic acid, the nucleus of kainoid amino acids

The distinctive nucleus of kainoid amino acids, (2S,3R)-(+)-2- carboxypyrrolidine- 3-acetic acid 6, was synthesized by a chemoenzymatic process, exploiting the diastereomeric cis/ trans methyl pyroglutamate derivatives 10a-c/11a-c as key intermediates. These mixtures, when subjected to a kinetic resolution mediated by α-chymotrypsin, reacted diastereo-, regio-, and enantioselectively to give the trans derivatives (+)-10a-c possessing the correct (2S,3R) configuration. Subsequently, the desired product (2S,3R)-(+)-6 could be obtained after well-established transformations.