1357488-40-4

Basic information

• Product Name: 5-(2-nitro-4-methylphenyl)-1H-1,2,3,4-tetrazole
• Synonyms: 5-(2-nitro-4-methylphenyl)-1H-1,2,3,4-tetrazole
• CAS NO: 1357488-40-4
• Molecular Weight: 205.176
• Mol File: 1357488-40-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 5-(2-nitro-4-methylphenyl)-1H-1,2,3,4-tetrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-nitro-4-methylphenyl)-1H-1,2,3,4-tetrazole(1357488-40-4)
• EPA Substance Registry System: 5-(2-nitro-4-methylphenyl)-1H-1,2,3,4-tetrazole(1357488-40-4)

Safety Data

• Hazardous Substances Data: 1357488-40-4(Hazardous Substances Data)

Upstream product

• 26830-95-5 4-methyl-2-nitrobenzonitrile 

Relevant articles and documents

InCl3-catalyzed [2+3] cycloaddition reaction: A rapid synthesis of 5-substituted 1H-tetrazole under microwave irradiation

A series of 5-substituted 1H-tetrazole were efficiently prepared by InCl3 catalyzed (10 mol %) from structurally divert organic nitriles with sodium azide under the influence of microwave irradiation. The present protocol was successfully applied to the aliphatic, aryl, benzylic and heterocyclic nitriles and corresponding 5-substituted 1H-tetrazole were obtained in good to excellent yield (70-96%). This method gives remarkable advantages such as short reaction time, simple work-up procedure and economical beneficial.

Green synthesis of 5-substituted-1H-1,2,3,4-tetrazoles and 1-sustituted-1H-1,2,3,4-tetrazoles via [3+2] cycloaddition by reusable immobilized AlCl3on -Al2O3

We report the effectiveness of the surface modified γ-Al2O3which is reusable, efficient, catalytic, safe and environmentally acceptable procedure for the conversion of both alkyl and aryl nitriles into the corresponding 5-substituted-1H-1,2,3,4-tetrazoles via [3+2] cycloaddition with sodium azide in excellent yields at mild reaction conditions (50 ° C). The catalyst also afforded 1-substituted-1H-1,2,3,4-tetrazoles by the reaction of amines, sodium azide and triethyl orthoformate. The catalyst could be recycled and was reused eleven runs without losing its activity.