13575-12-7Relevant academic research and scientific papers
Synthesis of 4-aryl-and 4-acyl-1,3-dithiole-2-thiones via deprotonative zincation of 1,3-dithiole-2-thione
Otsuka, Shinya,Yorimitsu, Hideki
, (2018)
We have developed deprotonative zincation of 1,3-dithiole- 2- thione at the 4-position. Addition of lithium diisopropylamide to a THF solution of 1,3-dithiole- 2- thione containing ZnI2 and LiI generated the corresponding organozinc species. After this zincation, various aryl and acyl groups were installed at the 4-position by Pd-catalyzed cross-coupling reaction with aryl iodides and Cu-catalyzed acylation with acyl chlorides, respectively.
