1357519-30-2Relevant academic research and scientific papers
SIAPhos: Phosphorylated sulfonimidamides and their use in iridium-catalyzed asymmetric hydrogenations of sterically hindered cyclic enamides
Patureau, Frederic W.,Worch, Christin,Siegler, Maxime A.,Spek, Anthony L.,Bolm, Carsten,Reek, Joost N. H.
, p. 59 - 64 (2012)
Phosphorylated sulfonimidamides (SIAPhos) undergo ion exchange reactions with cationic complexes, [Rh(cod)2BF4] and [Ir(cod) 2BarF], or neutral complexes [Rh(cod)Cl] 2 and [Ir(cod)Cl] 2, leading to unprecedented neutral complexes with PN- S-N chelates. Use of the resulting neutral iridium complexes in asymmetric hydrogenation reactions of tri- and tetrasubstituted enamides leads to products with high enantioselectivities (up to 92% ee).
