1357567-02-2Relevant academic research and scientific papers
Synthesis, biological evaluation and molecular docking studies of resveratrol derivatives possessing curcumin moiety as potent antitubulin agents
Ruan, Ban-Feng,Lu, Xiang,Li, Ting-Ting,Tang, Jian-Feng,Wei, Yao,Wang, Xiao-Liang,Zheng, Shi-Li,Yao, Ri-Sheng,Zhu, Hai-Liang
, p. 1113 - 1121 (2012)
A series of resveratrol derivatives possessing curcumin moiety were synthesized and evaluated for their antiproliferative activity against three cancer cell lines including murine melanoma B16-F10, human hepatoma HepG2 and human lung carcinoma A549. Among them, compound C5 displayed the most potent in vitro antiproliferative activity against B16-F10 with IC50 value of 0.71 μg/mL. Compound C5 also exhibited good tubulin polymerization inhibitory activity with IC50 value of 1.45 μg/mL. Furthermore, docking simulation was carried out to position C5 into the tubulin-colchicine binding site to determine the probable binding mode.
