1357567-07-7

Upstream product

• 1357567-41-9 (E)-4-(2,4-dimethoxy-6-((E)-4-methoxystyryl)phenyl)but-3-en-2-one 
• 446-52-6 2-Fluorobenzaldehyde 
• 906457-43-0 (E)-2,4-dimethoxy-6-(4-methoxystyryl) benzaldehyde 

Relevant academic research and scientific papers

pentadienone-resveratrol derivative, a method for producing the same, and an anticancer drug containing the same

The present invention relates to a pentadienone-resveratrol derivative useful as an anti-cancer drug, a preparing method thereof, and an anti-cancer drug including the same. The pentadienone-resveratrol derivative comprises a compound represented by chemi

Synthesis, biological evaluation and molecular docking studies of resveratrol derivatives possessing curcumin moiety as potent antitubulin agents

A series of resveratrol derivatives possessing curcumin moiety were synthesized and evaluated for their antiproliferative activity against three cancer cell lines including murine melanoma B16-F10, human hepatoma HepG2 and human lung carcinoma A549. Among them, compound C5 displayed the most potent in vitro antiproliferative activity against B16-F10 with IC50 value of 0.71 μg/mL. Compound C5 also exhibited good tubulin polymerization inhibitory activity with IC50 value of 1.45 μg/mL. Furthermore, docking simulation was carried out to position C5 into the tubulin-colchicine binding site to determine the probable binding mode.