1357582-01-4Relevant academic research and scientific papers
Structure-based design of potent and ligand-efficient inhibitors of CTX-M class A β-lactamase
Nichols, Derek A.,Jaishankar, Priyadarshini,Larson, Wayne,Smith, Emmanuel,Liu, Guoqing,Beyrouthy, Racha,Bonnet, Richard,Renslo, Adam R.,Chen, Yu
, p. 2163 - 2172 (2012)
The emergence of CTX-M class A extended-spectrum β-lactamases poses a serious health threat to the public. We have applied structure-based design to improve the potency of a novel noncovalent tetrazole-containing CTX-M inhibitor (Ki = 21 μM) mo
