1357583-98-2Relevant academic research and scientific papers
Towards chemical libraries based on heterocyclic scaffolds with monofluorinated and difluoroalkyl side chains
Bannwarth, Pierre,Grée, Danielle,Das, Saibal,Yadav, Jhillu Singh,Grée, René
experimental part, p. 180 - 187 (2012/02/17)
The preparation of focused chemical libraries, based on five- and six-membered heteroaromatic systems with mono- and gemdifluoroalkyl side chains, is described. Four heterocyclic scaffolds with a p-bromophenyl group have been easily prepared from readily available propargylic fluorides. Starting from these scaffolds, palladium-catalyzed reactions have been performed, including by automated procedures, to prepare libraries of molecules designed for biological applications.
