1357589-48-0

Basic information

• Product Name: 4-(1H-pyrazol-1-yl)pyridine hydrochloride
• Synonyms: 4-(1H-pyrazol-1-yl)pyridine hydrochloride
• CAS NO: 1357589-48-0
• Molecular Formula: C₈H₇N₃*ClH
• Molecular Weight: 181.62222
• Mol File: 1357589-48-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(1H-pyrazol-1-yl)pyridine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1H-pyrazol-1-yl)pyridine hydrochloride(1357589-48-0)
• EPA Substance Registry System: 4-(1H-pyrazol-1-yl)pyridine hydrochloride(1357589-48-0)

Safety Data

• Hazardous Substances Data: 1357589-48-0(Hazardous Substances Data)

Upstream product

• 288-13-1 NH-pyrazole 
• 7379-35-3 4-chlorpyridine hydrochloride 

Downstream Products

• 690261-87-1 4-(1H-pyrazol-1-yl)piperidine hydrochloride 
• 6091-44-7 piperidine hydrochloride 

Relevant articles and documents

A three-step synthesis of 4-(4-iodo-1H-pyrazol-1-yl)piperidine, a key intermediate in the synthesis of Crizotinib

4-(4-Iodo-1H-pyrazol-1-yl)piperidine is a key intermediate in the synthesis of Crizotinib. We report a robust three-step synthesis that has successfully delivered multi-kilogram quantities of the key intermediate. The process includes nucleophilic aromatic substitution of 4-chloropyridine with pyrazole, followed by hydrogenation of the pyridine moiety and subsequent iodination of the pyrazole which all required optimization to ensure successful scale-up.