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Usage

Uses

Used in Pharmaceutical Industry:
5-(4-Chlorophenyl)oxazol-2-amine is utilized as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the creation of complex molecular architectures with targeted biological activity, contributing to the development of new drugs with specific therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, 5-(4-Chlorophenyl)oxazol-2-amine serves as a valuable building block for the production of agrochemicals. Its reactivity and chemical properties make it suitable for the synthesis of compounds with pesticidal or herbicidal properties, enhancing crop protection and yield.
Used in Organic Chemistry Research:
5-(4-Chlorophenyl)oxazol-2-amine is also employed in organic chemistry research for studying the synthesis and reactions of heterocycles. Its presence in molecular structures can influence the reactivity and properties of organic compounds, providing insights into the design of novel chemical entities with potential applications in various fields.

Upstream product

• 76758-13-9 5-p-chlorophenyl-2-triphenylmethylaminooxazole 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 918164-36-0 1-[2-(4-chlorophenyl)-2-oxoethyl]pyrimidin-2(1H)-one 

Relevant academic research and scientific papers

Novel and efficient synthesis of 2-aminooxazoles from pyrimidin-2(1H)-one

Stepwise conversion of pyrimidin-2(1H)-one to 2-amino-5-aryloxazoles via oxazolo[3,2-a]pyrimidinium salts is reported. The sequence involves, (i) regioselective N-alkylation of pyrimidone by phenacyl bromides, (ii) cyclization of obtained 1-(2-aryl-2-oxoethyl)pyrimidin-2(1H)-ones into oxazolo[3,2-a] pyrimidinium salts under the action of fuming sulfuric (or triflic) acid, and (iii) reaction of the obtained salts with hydrazine leading to 2-amino-5-aryloxazoles. Georg Thieme Verlag Stuttgart.

Synthesis and reactions of N-o-anisylsulfonylmethyl- and N-o-sec-butoxysulfonylmethylcarbodiimides with aldehydes

N-o-Anisylsulfonylmethyl- and N-o-sec-butoxysulfonylmethyl-carbodiimides (2) and (3) have been synthesized from the corresponding sulfinic acids by Mannich reaction. 2 and 3 are useful synthons in two step synthesis of 2-amino-1,3-oxazoles(4).

Synthesis of N-(Tosylmethyl)carbodiimides and Their Application in the Synthesis of 2-Amino-1,3-oxazoles from Aldehydes

A series of N-(tosylmethyl)carbodiimides (TosCH2N=C=NR1, 3) have been prepared from the corresponding thioureas.Carbodiimides 3 with R1 = triphenylmethyl or tert-butyl are useful synthons in a new one-step synthesis of 2-(alkylamino)-1,3-oxazoles 10 from aromatic aldehydes.Acid-induced removal of the triphenylmethyl group from 10 gives 2-amino-1,3-oxazoles (11).