1357621-22-7

Basic information

• Product Name: [4-(5-{[({4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}amino)carbonyl]amino}-3-tert-butyl-1H-pyrazol-1-yl)phenyl]acetic acid
• Synonyms: [4-(5-{[({4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}amino)carbonyl]amino}-3-tert-butyl-1H-pyrazol-1-yl)phenyl]acetic acid
• CAS NO: 1357621-22-7
• Molecular Weight: 533.651
• Mol File: 1357621-22-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [4-(5-{[({4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}amino)carbonyl]amino}-3-tert-butyl-1H-pyrazol-1-yl)phenyl]acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(5-{[({4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}amino)carbonyl]amino}-3-tert-butyl-1H-pyrazol-1-yl)phenyl]acetic acid(1357621-22-7)
• EPA Substance Registry System: [4-(5-{[({4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}amino)carbonyl]amino}-3-tert-butyl-1H-pyrazol-1-yl)phenyl]acetic acid(1357621-22-7)

Safety Data

• Hazardous Substances Data: 1357621-22-7(Hazardous Substances Data)

Upstream product

• 1357620-87-1 4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-aminium chloride 
• 1357621-07-8 ethyl [4-(3-tert-butyl-5-{[(2,2,2-trichloroethoxy)carbonyl]amino}-1H-pyrazol-1-yl)phenyl]acetate 
• 147284-02-4 tert-butyl 4-(2-hydroxyethyl)-1,3-thiazol-2-ylcarbamate 
• 1357620-80-4 tert-butyl 4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-ylcarbamate 
• 53266-94-7 ethyl 2-amino-1,3-thiazol-4-acetate 
• 1197-55-3 4-aminophenylacetic acid 
• 57412-05-2 p-carboxymethylphenylhydrazine hydrochloride 
• 82548-78-5 ethyl {2-[(tert-butoxycarbonyl)amino]-1,3-thiazol-4-yl}acetate 

Relevant articles and documents

Structure-based design, synthesis and biological evaluation of N-pyrazole, N′-thiazole urea inhibitors of MAP kinase p38α

In this paper, we present the structure-based design, synthesis and biological activity of N-pyrazole, N′-thiazole-ureas as potent inhibitors of p38α mitogen-activated protein kinase (p38α MAPK). Guided by complex crystal structures, we employed the initially identified N-aryl, N′-thiazole urea scaffold and introduced key structural elements that allowed the formation of novel hydrogen bonding interactions within the allosteric site of p38α, resulting in potent type III inhibitors. [4-(3-tert-Butyl-5-{[(1,3-thiazol-2-ylamino)carbonyl]amino}-1H-pyrazol-1-yl) -phenyl]acetic acid 18c was found to be the most potent compound within this series and inhibited p38α activity with an IC50 of 135 ± 21 nM. Its closest analog, ethyl [4-(3-tert-butyl-5-{[(1,3-thiazol-2-ylamino) carbonyl]amino}-1H-pyrazol-1-yl)phenyl]acetate 18b, effectively inhibited p38α mediated phosphorylation of the mitogen activated protein kinase activated protein kinase 2 (MK2) in HeLa cells.