135776-86-2 Usage
Chemical Structure
Synthetic vitamin D derivative with a fluoride atom at the 24th position
Analog
Mimics the active form of vitamin D
Biological Effects
Regulation of calcium and phosphorus metabolism
Bone mineralization
Potential Therapeutic Applications
Treatment of vitamin D-related disorders and diseases
Osteoporosis
Renal osteodystrophy
Hypoparathyroidism
Anti-inflammatory properties
Anti-cancer properties
Research Status
Preclinical studies indicate promising results
Further research required for comprehensive understanding of therapeutic potential and side effects
Check Digit Verification of cas no
The CAS Registry Mumber 135776-86-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,5,7,7 and 6 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 135776-86:
(8*1)+(7*3)+(6*5)+(5*7)+(4*7)+(3*6)+(2*8)+(1*6)=162
162 % 10 = 2
So 135776-86-2 is a valid CAS Registry Number.
InChI:InChI=1/C28H43FO3/c1-18(13-15-28(6,29)26(3,4)32)23-11-12-24-20(8-7-14-27(23,24)5)9-10-21-16-22(30)17-25(31)19(21)2/h9-10,13,15,18,22-25,30-32H,2,7-8,11-12,14,16-17H2,1,3-6H3/b15-13+,20-9+,21-10-/t18-,22-,23-,24+,25?,27-,28-/m1/s1
135776-86-2Relevant academic research and scientific papers
A new synthesis of 24-fluoro-1α,25-dihydroxyvitamin D2 and its 24-epimer, and determination of the C-24 configuration
Hayashi,Ojima,Konno,Manaka,Yamaguchi,Yamada,Takayama
, p. 2932 - 2936 (2007/10/02)
A new synthesis of 24-fluoro-1α,25-dihydroxyvitamin D2 (4a) and its 24-epimer (4b) is described. Starting with 1α,3β-bis[(tert-butyldimethylsilyl)oxy]-24-norchol-5,7-dien-23-al (5), a mixture of 4a and 4b was obtained in 3% overall yield in 6 s
