1357912-49-2

Basic information

• Product Name: ((2R,3S,4S)-2-(3-chlorophenyl)-4-hydroxytetrahydrothiophen-3-yl)(phenyl)methanone
• CAS NO: 1357912-49-2
• Molecular Weight: 318.824
• Mol File: 1357912-49-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ((2R,3S,4S)-2-(3-chlorophenyl)-4-hydroxytetrahydrothiophen-3-yl)(phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: ((2R,3S,4S)-2-(3-chlorophenyl)-4-hydroxytetrahydrothiophen-3-yl)(phenyl)methanone(1357912-49-2)
• EPA Substance Registry System: ((2R,3S,4S)-2-(3-chlorophenyl)-4-hydroxytetrahydrothiophen-3-yl)(phenyl)methanone(1357912-49-2)

Safety Data

• Hazardous Substances Data: 1357912-49-2(Hazardous Substances Data)

Upstream product

• 40018-26-6 1,4-dithiane-2,5-diol 
• 22966-13-8 3-(3-chlorophenyl)-1-phenylprop-2-en-1-one 

Relevant articles and documents

Tri-substituted tetrahydro thiophene preparation method

The invention discloses a preparation method of tri-substituted tetrahydrothiophene. The preparation method comprises the following steps: performing reflux reaction on a substrate and 2,5-dihydroxyl 1,4-dithiane in water in the absence of a catalyst to obtain corresponding tri-substituted tetrahydrothiophene, wherein the substrate is a chalcone compound shown in a general formula 1, alpha, beta unsaturated ketone shown in a general formula 5 or trans-beta-nitroolefin shown in a general formula 8. The method for preparing tri-substituted tetrahydrothiophene through catalyst-free Sulfa-Michale/Aldol cascade reaction in the water is reported for the first time, and has the advantages of being relatively wide in substrate range, mild in reaction condition, simple, efficient, environment-friendly, low in cost and the like; the yield reaching up to 93% and the diastereomeric stereoselectivity exceeding 99: 1 can be achieved. The general formulas 1, 5 and 8 are shown in the specification.