1357927-91-3Relevant academic research and scientific papers
Intramolecular 1,3-dipolar cycloaddition of nitrile N-oxide accompanied by dearomatization
Yonekawa, Morio,Koyama, Yasuhito,Kuwata, Shigeki,Takata, Toshikazu
, p. 1164 - 1167 (2012/03/27)
Intramolecular 1,3-dipolar cycloaddition of 2-phenoxybenzonitrile N-oxides to benzene rings, accompanied by dearomatization, formed the corresponding isoxazolines in high yields. The X-ray single-crystal structure analysis revealed that the reaction formed the cis-adduct as a single isomer. The substituents on the benzene rings markedly affected the reaction rate, yield, and structure of the final product.
