1357928-21-2Relevant articles and documents
Design, synthesis and structure-activity relationship of novel Relacin analogs as inhibitors of Rel proteins
Wexselblatt, Ezequiel,Kaspy, Ilana,Glaser, Gad,Katzhendler, Joshua,Yavin, Eylon
, p. 497 - 504 (2013)
Rel proteins in bacteria synthesize the signal molecules (p)ppGpp that trigger the Stringent Response, responsible for bacterial survival. Inhibiting the activity of such enzymes prevents the Stringent Response, resulting in the inactivation of long-term
COMPOUNDS FOR TREATING BACTERIAL INFECTIONS
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, (2012/02/15)
The present invention generally relates to Rel proteins as a novel therapeutic target for treating bacterial threats. More specifically, the present invention relates to a novel class of compounds of formula (I) which inhibit RelA and/or Relseq and/or Rel