1357931-55-5

Basic information

• Product Name: Sildenafil EP IMpurity D
• Synonyms: Sildenafil EP IMpurity D;3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxybenzenesulfonic acid;Sildenafil impurity D
• CAS NO: 1357931-55-5
• Molecular Formula: C₁₇H₂₀N₄O₅S
• Molecular Weight: 474.5764
• Mol File: 1357931-55-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.48±0.1 g/cm3(Predicted)
• PKA: -0.81±0.50(Predicted)
• CAS DataBase Reference: Sildenafil EP IMpurity D(CAS DataBase Reference)
• NIST Chemistry Reference: Sildenafil EP IMpurity D(1357931-55-5)
• EPA Substance Registry System: Sildenafil EP IMpurity D(1357931-55-5)

Safety Data

• Hazardous Substances Data: 1357931-55-5(Hazardous Substances Data)

Usage

Uses

Demethylpiperazinyl Sildenafil Sulfonic Acid (Sildenafil EP Impurity D) is an impurity of Sildenafil citrate (S435000).

Upstream product

• 139756-02-8 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide 
• 139756-21-1 5-(2-ethoxy)-phenyl-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidine-7-one 
• 613-69-4 2-ethoxylbenzaldehyde 
• 139756-22-2 5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 
• 139755-83-2 viagra 

Downstream Products

• 139756-22-2 5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 
• 139755-83-2 viagra 
• 642928-07-2 5-[2-ethoxy-5-(4-ethylpiperazine-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 
• 1007310-62-4 C₂₇H₃₂N₆O₄S 
• 139755-85-4 5-[2-ethoxy-5-[4-(2-hydroxyethyl)-1-piperazinyl-sulphonyl]phenyl}-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 
• 1257393-31-9 5-[2-ethoxy-5-(4-methyl-1-homopiperazinylsulfonyl)]-phenyl-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo [4,3-d]pyrimidine-7-one 
• 226956-41-8 ethyl 4-((4-ethoxy-3-[1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-onyl]phenyl)sulfonyl)piperazinecarboxylate 

Relevant articles and documents

Sulphonated graphene oxide catalyzed continuous flow synthesis of pyrazolo pyrimidinones, sildenafil and other PDE-5 inhibitors

Sulphonated graphene oxide was used for cascade condensation and cyclization reactions towards accessing substituted pyrazolo pyrimidinones. Further, sulphonation and amination reactions were integrated through continuous flow chemistry to access PDE-5 inhibitors. Herein, we report a simple continuous synthetic platform that reduce tedious manual operations and accelerate the synthesis of several potent inhibitors of phosphodiesterase type-5. The developed platform enabled us to perform one-flow multi-step, multi-operational process to synthesize the PDE-5 inhibitors such as sildenafil and its analogues in 32.3 min of the reaction time, with minimal human intervention and single solvent.

A method for synthesis of impurity D Xidinafei (by machine translation)

The invention relates to a method for synthesis of impurity D Xidinafei, sulfuryl Xidinafei body chlorine to as raw material in the middle, the middle of the stated Xidinafei sulfurylbody chlorine in adding water and organic solvent, heating to reflux for