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1357945-49-3

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1357945-49-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1357945-49-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,7,9,4 and 5 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1357945-49:
(9*1)+(8*3)+(7*5)+(6*7)+(5*9)+(4*4)+(3*5)+(2*4)+(1*9)=203
203 % 10 = 3
So 1357945-49-3 is a valid CAS Registry Number.

1357945-49-3Downstream Products

1357945-49-3Relevant articles and documents

Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor

Chan, Bryan K.,Hanan, Emily J.,Bowman, Krista K.,Bryan, Marian C.,Burdick, Daniel,Chan, Emily,Chen, Yuan,Clausen, Saundra,Dela Vega, Trisha,Dotson, Jennafer,Eigenbrot, Charles,Elliott, Richard L.,Heald, Robert A.,Jackson, Philip S.,Knight, Jamie D.,La, Hank,Lainchbury, Michael D.,Malek, Shiva,Purkey, Hans E.,Schaefer, Gabriele,Schmidt, Stephen,Seward, Eileen M.,Sideris, Steve,Shao, Lily,Wang, Shumei,Yeap, Siew Kuen,Yen, Ivana,Yu, Christine,Heffron, Timothy P.

, p. 9080 - 9093 (2016)

Inhibitors targeting the activating mutants of the epidermal growth factor receptor (EGFR) have found success in the treatment of EGFR mutant positive non-small-cell lung cancer. A secondary point mutation (T790M) in the inhibitor binding site has been li

AZAINDAZOLE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS

-

, (2015/01/16)

This invention relates to novel compounds of formula (I), which are inhibitors of T790M containing EGFR mutants, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of cancer.

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