135799-32-5

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 135799-41-6 3,21-dichloro-11,13,29,31-tetramethyl-12,30-diphenyl-2,4,20,22-tetraoxa-10,11,13,14,28,29,31,32-octaaza-3,12,21,30-tetraphosphapentacyclo<32.2.2.2^5,8.2^16,19.2^23,25>tetratetraconta-5,7,9,14,16,18,23,25,27,32,34,36,37,39,41,43-hexadecene 3,12,21,... 
• 156457-81-7 bis(4-formylphenyl) azidothiophosphonate 

Relevant academic research and scientific papers

Phosphite sodium salt modified amphipathic phosphorus-containing crown macromolecule nano micelle and preparation and application thereof

The invention relates to a phosphite sodium salt modified amphipathic phosphorus-containing crown macromolecule nano micelle and a preparation method and application thereof. The preparation method is simple, the controllability of the reaction process is high, and the operation is easy. Compared with the reported polyamide - amine type crown macromolecule nano-micelle, the nano material has higher encapsulation efficiency, loading rate and better anti-inflammatory effect, can effectively improve the treatment effect of the hydrophobic drug, and has good application prospects.

Preparation method of amphiphilic PN = PS type phosphorus-containing crown macromolecular nano-micelle and application of crown macromolecular nano-micelle as drug carrier

The invention relates to a preparation method of amphipathic PN = PS type phosphorus-containing crown macromolecule nano-micelle and application of the crown macromolecular nano-micelle as a drug carrier. The obtained amphipathic phosphorus-containing crown macromolecule can be self-assembled into the nano-micelle in water, and a hydrophobic drug can be embedded into a hydrophobic cavity in the nano-micelle to form a stable compound. The method disclosed by the invention is simple, high in reaction controllability, easy in operation and separation, low in cost, uniform in final product molecular weight and commercialized in raw material source, and has a good development prospect.

Synthesis of di- or tetrafunctionalized phosphorus macrocycles

The reaction of functionalized phosphodihydrazides RP(X)[NMeNH2]2 (R = Cl, N3) (1) with organic (2) or phosphorus (4) dialdehydes leads to the synthesis of di- or tetrafunctionalized phosphorus macrocycles 3a-d, 5a-h in go