13582-96-2Relevant academic research and scientific papers
Green technology for preparing dioxopromethazine hydrochloride by using oxygen as oxidant
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Paragraph 0012; 0014, (2017/07/21)
The invention discloses a green technology for preparing dioxopromethazine hydrochloride by using oxygen as an oxidant, and belongs to the technical field of medical intermediates. The green technology is characterized in that a target product-the dioxopromethazine hydrochloride can be obtained through a series of reaction by using the oxygen as the oxidant and adopting palladium acetate as a catalyst, and a production process is greatly simplified; compared with a method of using hydrogen peroxide as the oxidant, the yield of an intermediate is much higher, a whole oxidation process requires no addition of sulfuric acid or the hydrogen peroxide, a final product is powder which is white to yellowish or crystalline powder, and the final product is odorless and is bitter in taste and very high in purity. By adopting an improved synthesis path, the green technology disclosed by the invention has multiple advantages that the yield is increased to a large extent, the cost is reduced, safety is increased, energy is saved, and the like, and modern chemical industry production requirements of green reaction are met.
