135824-32-7Relevant academic research and scientific papers
2′,3′-Cyclopropanated Nucleoside Dimers
Yannopoulos, Constantin G.,Zhou, Wen-Qiang,Nower, Peter,Peoc'h, Didier,Sanghvi, Yogesh S.,Just, George
, p. 378 - 380 (2007/10/03)
Syntheses of three novel conformationally rigid dimers containing cyclopropyl -amide and -sulfonamide functionalities are described. Their incorporation into an oligonucleotide sequence resulted in considerable lowering of the Tm's in binding to their complementary RNA sequences.
Selenoxide Elimination for the Synthesis of Unsaturated-Sugar Uracil Nucleosides
Haraguchi, Kazuhiro,Tanaka, Hiromichi,Maeda, Hideaki,Itoh, Yoshiharu,Saito, Shigeru,Miyasaka, Tadashi
, p. 5401 - 5408 (2007/10/02)
Introduction of a phenylseleno group to the sugar portion of uracil nucleosides and selenoxide elimination reactions of the resulting selenium-containing derivatives are described.A phenylselenide anion prepared by reducing (PhSe)2 with LiAlH4 was found to be highly reactive.By using this selenide as a nucleophile, ring openings of various types of cyclonucleosides and nucleosides having an anhydro structure in the sugar portion were accomplished.The products, which contain a phenylseleno group in the sugar portion, were oxidized with m-CPBA in CH2Cl2, and their susceptibility to the selenoxide elimination and regiochemistry of the reaction was investigated.
