135841-62-2

Basic information

• Product Name: 1-[(3-chlorophenyl)carbonyl]-4-phenyl thiosemicarbazide
• Synonyms: 1-[(3-chlorophenyl)carbonyl]-4-phenyl thiosemicarbazide
• CAS NO: 135841-62-2
• Molecular Weight: 305.788
• Mol File: 135841-62-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1-[(3-chlorophenyl)carbonyl]-4-phenyl thiosemicarbazide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(3-chlorophenyl)carbonyl]-4-phenyl thiosemicarbazide(135841-62-2)
• EPA Substance Registry System: 1-[(3-chlorophenyl)carbonyl]-4-phenyl thiosemicarbazide(135841-62-2)

Safety Data

• Hazardous Substances Data: 135841-62-2(Hazardous Substances Data)

Upstream product

• 5285-87-0 phenyl thiocyanate 
• 1673-47-8 3-chlorobenzhydrazide 
• 1128-76-3 3-chloro-benzoic acid ethyl ester 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 1422706-92-0 5-(3-chlorophenyl)-N-phenyl-1,3,4-oxadiazole-2-amine 
• 93717-11-4 5-(3-chlorophenyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione 
• 135815-50-8 Pd(C₆H₅NHCSNHNHCOC₆H₄-m-Cl)Cl₂ 

Relevant articles and documents

A KHSO4 mediated facile synthesis of 2-amino-1,3,4-oxadiazole derivatives

A novel, efficient and mild KHSO4 mediated synthesis for 2-amino-1,3,4-oxadiazoles has been established via the cyclodesulfurization of benzoylhydrazine and isothiocyanate derivatives in one pot. The reactions proceeded smoothly at room tempera

A new and efficient synthesis of 1,3,4-oxadiazole derivatives using TBTU

An efficient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from isothiocyanates and hydrazides through cyclodesulfurization in the presence of (O-(benzotriazol-1-yl)-N,N,N′, N′-tetramethyluronium tetrafluoroborate) TBTU as an uronium cou

Synthesis and antimicrobial activity of thiosemicarbazides, s-triazoles and their Mannich bases bearing 3-chlorophenyl moiety

A fast and efficient synthesis of some 1,4-disubstituted thiosemicarbazide derivatives is described. The reaction of 3-chlorobenzoic acid hydrazide with various aryl isothiocyanates gave thiosemicarbazide derivatives (1-11) in good yield. The cyclization of compounds (1-11) in the presence of 2% NaOH resulted in the formation of compounds (12-22) containing the 1,2,4-triazole ring. A series of new Mannich bases (23-33) related to the structure of 1,2,4-triazole has been also synthesized. All of these compounds were tested for their in vitro antibacterial activity against the reference strains of aerobic bacteria - 6 Gram-positive and 3 Gram-negative ones; 12 Staphylococcus aureus clinical isolates were also examined. An attempt was made to clarify the influence of the nature/position of substituents on antibacterial activity of compounds described.