135859-37-9

Usage

Uses

Used in Organic Synthesis:
(3R)-4,4,4-trifluoro-1-(4-methylbenzenesulfonate)-1,3-Butanediol is used as a building block in organic synthesis for constructing more complex molecules. Its trifluoro and sulfonate groups provide specific reactivity and properties that facilitate certain reactions.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (3R)-4,4,4-trifluoro-1-(4-methylbenzenesulfonate)-1,3-Butanediol is used as a starting material for the development of pharmaceutical compounds. Its unique structure and properties make it a promising candidate for the synthesis of new drugs with potential therapeutic applications.
Used in Fine Chemicals Industry:
(3R)-4,4,4-trifluoro-1-(4-methylbenzenesulfonate)-1,3-Butanediol is also used in the fine chemicals industry as a key intermediate in the synthesis of specialty chemicals. Its chiral nature and functional groups contribute to the development of high-value products with specific applications.
The precise applications and uses of (3R)-4,4,4-trifluoro-1-(4-methylbenzenesulfonate)-1,3-Butanediol depend on its specific properties and how it is utilized in various chemical reactions. Its versatility and unique structure make it a valuable asset in the fields of organic synthesis, pharmaceutical development, and fine chemicals production.

Upstream product

• 433-25-0 (±)-4,4,4-trifluorobutane-1,3-diol 
• 98-59-9 p-toluenesulfonyl chloride 
• 433-25-0 (R)-4,4,4-trifluorobutane-1,3-diol 

Downstream Products

• 121170-45-4 (2R)-1,1,1-trifluorooctan-2-ol 

Relevant academic research and scientific papers

SYNTHESE DE LA TRIFLUOROMETHYL-VINYL-CETONE

The synthesis of trifluoromethylvinylketone 6 is described.The metal hydride reduction of ethyl trifluoroacetoacetate 1 gives the glycol 2.Selective tosylation of 2 occurs on the primary hydroxyl group and leads to 3.Tosyl-chloride exchange produces the c

The fluorine-containing α, β - production of unsaturated aldehydes

The purpose of the present invention is to provide a fluorine-containing alpha,beta-unsaturated aldehyde, a method for producing same, an optically active fluorine-containing compound using the fluorine-containing alpha,beta-unsaturated aldehyde, and a method for producing same. This method for producing a fluorine-containing alpha,beta-unsaturated aldehyde is a method for producing a fluorine-containing alpha,beta-unsaturated aldehyde represented by formula (1) and comprises: an oxidizing step of oxidizing an alcohol represented by formula (2) in a high-boiling-point solvent, which has a higher boiling point than the corresponding alpha,beta-unsaturated aldehyde, by using an oxidizing agent that is insoluble to the high-boiling-point solvent; and a purifying step of purifying the reaction solution obtained in the oxidizing step by distillation. In formulae (1) and (2), R1 and R2 each independently represent a hydrogen atom or a fluorine atom, and X is 2 or 3.

Nucleophilic trifluoromethylation of conjugate acceptors via phenyl trifluoromethyl sulfone

A mild procedure for the conjugate addition of the trifluoromethyl anion to activated Michael acceptors such as arylidenemalononitriles (15 examples) and arylidene Meldrum's acids (9 examples) using phenyl trifluoromethyl sulfone through a reductive magnesium metal mediated procedure is described. The new methodology is used to prepare befloxatone, a reversible and selective monoamine oxidase A inhibitor.

Practical synthesis of 4,4,4-trifluorocrotonaldehyde: A versatile precursor for the enantioselective formation of trifluoromethylated stereogenic centers via organocatalytic 1,4-additions

The practical synthesis of 4,4,4-trifluorocrotonaldehyde (1) and its application to enantioselective 1,4-additions are described. The organocatalytic 1,4-addition of 1 with several nucleophiles such as heteroaromatics, alkylthiols and aldoximes afforded t

Synthesis and Spin-Trapping Chemistry of 5,5-Dimethyl-2-(trifluoromethyl)-1-pyrroline N-Oxide

A new five-membered ring nitrone, 5,5-dimethyl-2-(trifluoromethyl)-1-pyrroline N-oxide (2-TFDMPO), is synthesized for the purpose of spin trapping in free radical biology.Most of the spin adducts of 2-TFDMPO are persistent, and EPR, ENDOR, and MS spectra can be obtained.A variety of radicals give characteristic spectral signatures, among which is a rare type of line width alternation pattern due to hindered rotation of the trifluoromethyl group.